Valdar Lab

Literature

Publications

Full citations of papers are followed by strings such as

PMID:19474203 PMCID:PMC2728864
The "PMID" links to the PubMed page of the article. The ":" that immediately follows links to UNC's own PubMed library proxy, which if you are at UNC typically includes full text access. The PubMed identifier "19474203" is given as plain text, for ease of copying. The "PMCID" links to the article at the PubMedCentral website, which houses free copies of all papers that have been funded by NIH and are more than a year old. The PubMedCentral number "PMC2728864" is given as plain text, again, for ease of copying. If you cannot access a paper using one of these methods, you can request the pdf from me.

* indicates joint authorship.

    2014

  1. Crowley JJ*, Kim Y*, Lenarcic AB*, Quackenbush CR, Barrick C, Adkins DE, Shaw GS, Miller DR, Pardo Manuel de Villena F, Sullivan PF, Valdar W (2014) Genetics of adverse reactions to haloperidol in a mouse diallel: A drug-placebo experiment and Bayesian causal analysis. Genetics 196(1):321-47 PMID:24240528 PMCID:PMC3872195
  2. Phillippi J*, Xie Y*, Miller DR, Bell TA, Zhang Z, Lenarcic AB, Aylor DL, Krovi SH, Threadgill DW, Pardo-Manuel de Villena F, Wang W, Valdar W*, Frelinger JA* (2014) Using the Collaborative Cross to probe the immune system. Genes and Immunity 15(1):38-46 PMID:24195963
  3. 2013

  4. Calaway J, Lenarcic AB, Didion JP, Wang JR, Searle JB, McMillan L, Valdar W, Pardo-Manuel de Villena F (2013) Genetic architecture of skewed X inactivation in the laboratory mouse. PLoS Genetics 9(10):e1003853 PMID:24098153 PMCID:PMC3789830
  5. Ferris MT, Aylor DL, Bottomly D, Whitmore AC, Aicher LD, Bell TA, Bradel-Tretheway B, Bryan JT, Buus RJ, Gralinski LE, Haagmans BL, McMillan L, Miller DR, Rosenzweig E, Valdar W, Wang J, Churchill GA, Threadgill DW, McWeeney SK, Katze MG, Pardo-Manuel de Villena F, Baric RS, Heise MT (2013) Modeling host genetic regulation of influenza pathogenesis in the Collaborative Cross. PLoS Pathogens 9(2):e1003196 PMID:23468633 PMCID:PMC3585141
  6. 2012

  7. Solberg Woods LC, Holl KL, Oreper D, Xie Y, Tsaih S-W, Valdar W (2012) Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats. Physiological Genomics 44(21):1013-26 PMID:22947656 PMCID:PMC3524769
  8. Rönnegård L, Valdar W (2012) Recent developments in statistical methods for detecting genetic loci affecting phenotypic variability. BMC Genetics 13(1):63 PMID:22827487 PMCID:PMC3493319
  9. Valdar W*, Sabourin J*, Nobel A, Holmes C (2012) Reprioritizing genetic associations in hit regions using LASSO-based resample model averaging. Genetic Epidemiology 36(5):451-462 PMID:22549815
  10. Lenarcic AB, Svenson KL, Churchill GA, Valdar W (2012) A general Bayesian approach to analyzing diallel crosses of inbred strains. Genetics 190(2):413-435. PMID:22345610 PMCID:PMC3276624
  11. Svenson KL, Gatti DM, Valdar W, Welsh CE, Cheng R, Chesler EJ, Palmer AA, McMillan L, Churchill GA (2012) The Mouse Diversity Outbred Population. Genetics 190(2):437-447. PMID:22345611 PMCID:PMC3276626
  12. Zhang W, Korstanje R, Thaisz J, Staedtler F, Harttman N, Xu L, Feng M, Yanas L, Yang H, Valdar W, Churchill GA, DiPetrillo K (2012) Genomewide association mapping of quantitative traits in outbred mice. G3: Genes, Genomes, Genetics 2(2):167-174. PMID:22384395 PMCID:PMC3284324
  13. Collaborative Cross Consortium (2012) The genome architecture of the Collaborative Cross mouse genetic reference population. Genetics 190(2):389-401. PMID:22345608 PMCID:PMC3276630
  14. 2011

  15. Rönnegård L, Valdar W (2011) Detecting major genetic loci controlling phenotypic variability in experimental crosses. Genetics 188:435-447. PMID:21467569 PMCID:PMC3122324
  16. Johnsen AK*, Valdar W*, Golden L, Ortiz-Lopez A, Hitzemann R, Flint J, Mathis D, Benoist C (2011) Genetics of arthritis severity: a genome-wide and species-wide dissection in HS mice. Arthritis & Rheumatism 63(9):2630-2640. PMID:21560115
  17. Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Didion JP, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SNP, Collins FS, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill D, Pardo-Manuel de Villena F, Churchill GA (2011) Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Research 21(8):1213-1222. PMID:21406540 PMCID:PMC3149489
  18. Ahlqvist E, Ekman D, Lindvall T, Popovic M, Förster M, Hultqvist M, Klaczkowska D, Teneva I, Johannesson M, Flint J, Valdar W, Nandakumar KS, Holmdahl R (2011) High resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice. Human Molecular Genetics 20(15):3031-3041. PMID:21565963
  19. 2010

  20. Solberg Woods L, Holl K, Tschannen M, Valdar W (2010) Fine-mapping a locus for glucose tolerance using heterogeneous stock rats. Physiological Genomics 41(1):102-8. PMID:20068026 PMCID:PMC2841497
  21. 2009

  22. Valdar W, Holmes CC, Mott R, Flint J (2009) Mapping in structured populations by resample model averaging. Genetics 182(4):1263-77. PMID:19474203 PMCID:PMC2728864
  23. Kover PX, Valdar W, Trakalo J, Scarcelli N, Ehrenreich IM, Purugganan MD, Durrant C, Mott R (2009) A Multiparent Advanced Generation Inter-Cross to fine-map quantitative traits in Arabidopsis thaliana. PLoS Genetics 5(7):e1000551 PMID:19593375 PMCID:PMC2700969
  24. Huang GJ, Shifman S, Valdar W, Johannesson M, Yalcin B, Taylor MS, Taylor JM, Mott R, Flint J (2009) High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Research 19(6):1133-40. PMID:19376938 PMCID:PMC2694476
  25. Ramagopalan SV, Valdar W, Criscuoli M, Deluca GC, Dyment DA, Orton SM, Yee IM, Ebers GC, Sadovnick AD; for the Canadian Collaborative Study Group (2009) Age of puberty and the risk of multiple sclerosis: a population based study. Eur J Neurol 16(3):342-7. PMID:19170744
  26. Ramagopalan SV, Valdar W, Dyment DA, DeLuca GC, Yee IM, Giovannoni G, Ebers GC, Sadovnick AD; Canadian Collaborative Study Group (2009) Association of infectious mononucleosis with multiple sclerosis: a population-based study. Neuroepidemiology 32(4):257-62. PMID:19209005
  27. Bice P, Valdar W, Zhang L, Liu L, Lai D, Grahame N, Flint J, Li TK, Lumeng L, Foroud T (2009) Genomewide SNP Screen to Detect Quantitative Trait Loci for Alcohol Preference in the High Alcohol Preferring and Low Alcohol Preferring Mice. Alcohol Clin Exp Res 33(3):531-7. PMID:19120064 PMCID:PMC2867232
  28. López-Aumatell R, Vicens-Costa E, Guitart-Masip M, Martínez-Membrives E, Valdar W, Johannesson M, Cañete T, Blázquez G, Driscoll P, Flint J, Tobeña A, Fernández-Teruel A (2009) Unlearned anxiety predicts learned fear: a comparison among heterogeneous rats and the Roman rat strains. Behav Brain Res. 202(1):92-101. PMID:19447285
  29. Wallis-Owen SAG, Valdar W (2009) Deciphering gene-environment interactions through mouse models of allergic asthma. Journal of Allergy and Clinical Immunology 123(1):14-23. PMID:18926561
  30. Johannesson M, Lopez-Aumatell R, Stridh P, Diez M, Tuncel J, Blázquez G, Martinez-Membrives E, Cañete T, Vicens-Costa E, Graham D, Copley RR, Hernandez-Pliego P, Beyeen AD, Ockinger J, Fernández-Santamaría C, Gulko PS, Brenner M, Tobeña A, Guitart-Masip M, Giménez-Llort L, Dominiczak A, Holmdahl R, Gauguier D, Olsson T, Mott R, Valdar W, Redei EE, Fernández-Teruel A, Flint J (2009) A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Res 19(1):150-8. PMID:18971309 PMCID:PMC2612958.
  31. 2008

  32. Ramagopalan SV, Herrera BM, Valdar W, Dyment DA, Orton SM, Yee IM, Criscuoli M, Atkins K, Ebers GC, Sadovnick AD (2008) No Effect of Birth Weight on the Risk of Multiple Sclerosis. A Population-Based Study. Neuroepidemiology 31(3):181-184. PMID:18784417
  33. Ramagopalan SV, Valdar W, Dyment DA, DeLuca GC, Orton SM, Yee IM, Criscuoli M, Ebers GC, Sadovnick AD; Canadian Collaborative Study Group (2008) No effect of preterm birth on the risk of multiple sclerosis: a population based study. BMC Neurology 8:30 PMID:18673559
  34. Lopez-Aumatell R, Guitart-Masip M, Vicens-Costa E, Gimenez-Llort L, Valdar W, Johannesson M, Flint J, Tobeña A, Fernandez-Teruel A (2008) Fearfulness in a large N/Nih genetically heterogeneous rat stock: differential profiles of timidity and defensive flight in males and females. Behav Brain Res 188(1):41-55. PMID:18079010
  35. 2007

  36. Ramagopalan SV, Dyment DA, Valdar W, Herrera BM, Criscuoli M, Yee IM, Sadovnick AD, Ebers GC; Canadian Collaborative Study Group (2007) Autoimmune disease in families with multiple sclerosis: a population-based study. Lancet Neurology 6(7):604-10 PMID:17560172
  37. Keays DA, Tian G, Poirier K, Huang GJ, Siebold C, Cleak J, Oliver PL, Fray M, Harvey RJ, Molnár Z, Piñon MC, Dear N, Valdar W, Brown SD, Davies KE, Rawlins JN, Cowan NJ, Nolan P, Chelly J, Flint J (2007) Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans. Cell 128(1):45-57. PMID:17218254
  38. Taylor M, Valdar W, Flint J, Mott R (2007) Management, presentation and interpretation of genome scans using GSCANDB. Bioinformatics 15;23(12):1545-9 PMID:17400728
  39. Keays DA, Clark TG, Campbell TG, Broxholme J, Valdar W (2007) Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: Revisited. Mammalian Genome 18(2):123-4 PMID:17347895
  40. 2006

  41. Valdar W, Solberg LC, Gaugier D, Cookson WO, Rawlins JNP, Mott R, Flint J (2006) Genetic and environmental effects on complex traits in mice. Genetics 174(2):959-84. PMID:16888333 PMCID:PMC1602068
  42. Orton S, Herrera BM, Yee IM, Valdar W, Ramaglopalan SV, Sadovnick AD, Ebers GC Canadian Collaborative Study Group (2006) Lancet Neurology 5(11):932-6. PMID:17052660
  43. Valdar W, Solberg LC, Gaugier D, Burnett S, Klenerman P, Cookson WO, Taylor M, Rawlins JNP, Mott R, Flint J (2006) Genome-wide genetic association of complex traits in outbred mice. Nature Genetics 38(8):879-87. PMID:16832355
  44. Solberg LC, Valdar W, Gauguier D, Nunez G, Taylor A, Hernandez P, Davidson S, Burns P, Cookson W, Deacon R, Rawlins JNP, Mott R, Flint J (2006) A protocol for high throughput phenotyping, suitable for quantitative trait analysis in mice. Mammalian Genome 17(2):129-46 PMID:16465593
  45. Valdar W, Mott R, Flint J (2006) Simulating the collaborative cross: power of QTL detection and mapping resolution in large sets of recombinant inbred strains of mice. Genetics 172(3):1783-97. PMID:16361245 PMCID:PMC1456308
  46. 2005

  47. Flint J, Valdar W, Shifman S, Mott R (2005) Experimental strategies for mapping and cloning quantitative trait genes in rodents. Nature Reviews Genetics 6(4):271-286. PMID:15803197
  48. 2004

  49. Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpaa MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F; Complex Trait Consortium (2004) The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics 36(11):1133-7. PMID:15514660
  50. 2003

  51. Valdar WSJ , Mott R, Flint J (2003) QTL fine-mapping with recombinant-inbred heterogeneous stocks and in-vitro heterogeneous stocks. Mammalian Genome 14(12):830-838. PMID:14724734
  52. 2002 and earlier

  53. Valdar WSJ (2002) Scoring residue conservation. Proteins: Structure, Function, and Genetics 43(2): 227-241. PMID:12112692 Errata
  54. Nobeli I, Laskowski RA, Valdar WSJ, Thornton JM (2001) On the molecular discrimination between adenine and guanine in proteins. Nucleic Acids Research 29(21):4294-4309. PMID:11691917
  55. Valdar WSJ, Thornton JM (2001) Conservation helps to identify biologically relevant crystal contacts. Journal of Molecular Biology 313(2):399-416. PMID:11800565 Errata
  56. Valdar WSJ, Thornton JM (2001) Protein-protein interfaces: analysis of amino acid conservation in homodimers. Proteins: Structure, Function, and Genetics 42(1):108-124. PMID:11093265

Book Chapters

Valdar WSJ & Jones DT (2002) Amino acid residue conservation. In Bioinformatics: Sequence, Structure, Function (Orengo, CA, Thornton JM, Jones DT Eds). BIOS Scientific Publishers Ltd, Oxford. Amazon


Theses

Valdar WSJ (2003) Detection of epistatic quantitative trait loci in murine heterogeneous stock recombinant inbred lines. MSc thesis (subject: applied statistics), Oxford University.

Valdar WSJ (2001) Residue conservation in the prediction of protein-protein interfaces. PhD thesis (subject: protein structure bioinformatics), University College London. PDF

Valdar WSJ (1998) J-Features: development of a java-based feature table editor. MSc thesis (subject: bioinformatics), Manchester University. PDF